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Women with Turner syndrome may experience adverse psychosocial outcomes which can be improved through early intervention and the provision of appropriate psychological and psychiatric care. Genetic, hormonal, and medical problems associated with TS are likely to affect psychosexual development of female adolescent patients, and thus influence their psychological functioning, behavior patterns, social interactions, and learning ability. Although TS constitutes a chronic medical condition, with possible physical, social, and psychological complications in a woman s life, hormonal and estrogen replacement therapy, and assisted reproduction, are treatments that can be helpful for TS patients and improve their quality of life.

Women with Turner syndrome are almost universally infertile. Reproductive Edit. 38 39 Even when such pregnancies do occur, there is a higher than average risk of miscarriage or birth defects, including Turner syndrome or Down syndrome. While some women with Turner syndrome have successfully become pregnant and carried their pregnancies to term, this is very rare and is generally limited to those women whose karyotypes are not 45,X. 36 Research shows a possible association between age at diagnosis and increased substance use and depressive symptoms.

40 Some women with Turner syndrome who are unable to conceive without medical intervention may be able to use IVF or other fertility treatments. Usually, estrogen replacement therapy is used to spur the growth of secondary sexual characteristics at the time when puberty should onset. While very few women with Turner syndrome menstruate spontaneously, estrogen therapy requires a regular shedding of the uterine lining withdrawal bleeding to prevent its overgrowth.

Withdrawal bleeding can be induced monthly, like menstruation, or less often, usually every three months, if the patient desires. Estrogen therapy does not make a woman with nonfunctional ovaries fertile, but it plays an important iq option taxas in assisted reproduction; the health of the uterus must be maintained with estrogen if an eligible woman with Turner Syndrome wishes to use IVF using donated oocytes.

45,X 46,XY due to the risk of development of ovarian malignancy most common is gonadoblastoma gonadectomy is recommended. Especially in mosaic cases of Turner syndrome that contains Y-chromosome e. 27 42 Turner syndrome is characterized by primary amenorrhoea, premature ovarian failure hypergonadotropic hypogonadismstreak gonads and infertility however, technology especially oocyte donation provides the opportunity of pregnancy in these patients. Failure to develop secondary sex characteristics sexual infantilism is typical.

As more women with Turner syndrome complete pregnancy thanks to modern techniques to treat infertility, it has to be noted that pregnancy may be a risk of cardiovascular complications for the mother. Indeed, several studies had suggested an increased risk for aortic dissection in pregnancy. It seems that the high risk of aortic dissection during pregnancy in women with Turner syndrome may be due to the increased hemodynamic load rather than the high estrogen rate.

27 Of course, these findings are important and need to be remembered while following a pregnant patient with Turner syndrome. Hearing Edit. Recurrent acute otitis media AOM and otitis media with effusion OME commonly occur in children with Turner syndrome during the preschool age, which can persist or develop later in childhood. The recurring AOM can also be a predisposition to cholesteatomas. 43 44 People with the monosomy 45, X karyotype have an increased rate of hearing loss over other TS karyotype variants.

Conductive hearing losses are more commonly seen with children than adults and becomes more of a sensorineural pattern once in the adolescence age. There seems to be an apparent linear relation between hearing loss and age in TS. 45 46 About 75 of people with Turner syndrome have some hearing loss, with the most common presenting as a high frequency sensorineural hearing loss HFSNHL across all ages. 29 The influence of estrogen has been examined but remains unclear.

47 48 49 People with TS tend to have more of a progressive hearing loss with a higher decline rate than those in their corresponding age groups with hearing loss. The increased decline tends to occur in the higher frequency range, with a rate of around 0. Turner syndrome is caused by the absence of one complete or partial copy of the X chromosome in some or all the cells. The abnormal cells may have only one X monosomy 45,X or they may be affected by one of several types of partial monosomy like a deletion of the short p arm of one X chromosome 46,X,del Xp or the presence of an isochromosome with two q arms 46,X,i Xq 51 Turner syndrome has distinct features due to the lack of pseudoautosomal regions, which are typically spared from X-inactivation.

5 In mosaic individuals, cells with X monosomy 45,X may occur along with cells that are normal 46,XXcells that have partial monosomies, or cells that have a Y chromosome 46,XY. 51 The presence of mosaicism is estimated to be relatively common in affected individuals 67 90. Inheritance Edit. In the majority of cases where monosomy occurs, the X chromosome comes from the mother.

52 This may be due to a nondisjunction in the father. Meiotic errors that lead to the production of X with p arm deletions or abnormal Y chromosomes are also mostly found in the father. 53 Isochromosome X or ring chromosome X on the other hand are formed equally often by both parents. 53 Overall, the functional X chromosome usually comes from the mother. In most cases, Turner syndrome is a sporadic event, and for the parents of an individual with Turner syndrome the risk of recurrence is not increased for subsequent pregnancies.

Rare exceptions may include the presence of a balanced translocation of the X chromosome in a parent, or where the mother has 45,X mosaicism restricted to her germ cells. Turner syndrome may be diagnosed by amniocentesis or chorionic villus sampling during pregnancy.heart defect, kidney abnormality, cystic hygroma, ascites. Usually, fetuses with Turner syndrome can be identified by abnormal ultrasound findings i.

In a study of 19 European registries, 67. 2 of prenatally diagnosed cases of Turner syndrome were detected by abnormalities on ultrasound. 1 of cases had one anomaly present, and 30. 9 had two or more anomalies. An increased risk of Turner syndrome may also be indicated by abnormal triple or quadruple maternal serum screen. The fetuses diagnosed through positive maternal serum screening are more often found to have a mosaic karyotype than those diagnosed based on ultrasonographic abnormalities, and conversely, those with mosaic karyotypes are less likely to have associated ultrasound abnormalities.

Postnatal Edit. Turner syndrome can be diagnosed postnatally at any age. Often, it is diagnosed at birth due to heart problems, an unusually wide neck or swelling of the hands and feet. However, it is also common for it to go undiagnosed for several years, often until the girl reaches the age of puberty and fails to develop typically the changes associated with puberty do not occur.

In childhood, a short stature can be indicative of Turner syndrome. A test called a karyotype, also known as a chromosome analysis, analyzes the chromosomal composition of the individual. This is the test of choice to diagnose Turner syndrome. As a chromosomal condition, there is no cure for Turner syndrome. However, much can be done to minimize the symptoms. For example 57. Growth hormone, either alone or with a low dose of androgen, will increase growth and probably final adult height.

Growth hormone is approved by the U. Food and Drug Administration for treatment of Turner syndrome and is covered by many insurance plans. 57 58 There is evidence that this is effective, even in toddlers. 59 Estrogen replacement therapy such as the birth control pill, has been used since the condition was described in 1938 to promote development of secondary sexual characteristics.

57 Women with Turner syndrome who do not have spontaneous puberty and who are not treated with estrogen are at high risk for osteoporosis and heart conditions. Estrogens are crucial for maintaining good bone integrity, cardiovascular health and tissue health. Modern reproductive technologies have also been used to help women with Turner syndrome become pregnant if they desire. For example, a donor egg can be used to create an embryo, which is carried by the Turner syndrome woman.

57 Uterine maturity is positively associated with years of estrogen use, history of spontaneous menarche, and negatively associated with the lack of current hormone replacement therapy. Turner syndrome occurs in between one in 2000 6 and one in 5000 females at birth. Approximately 99 percent of fetuses with Turner syndrome spontaneously terminate during the first trimester.

61 Turner syndrome accounts for about 10 percent of the total number of spontaneous abortions in the United States. 62 In Europe, it is often called Ullrich Turner syndrome or even Bonnevie Ullrich Turner syndrome to acknowledge that earlier cases had also been described by European doctors. The syndrome is named after Henry Turner, an endocrinologist from Illinois, who described it in 1938. In Russian and USSR literature it is called Shereshevsky Turner syndrome to acknowledge that the condition was first described as hereditary in 1925 by the Soviet endocrinologist Nikolai Shereshevsky ruwho believed that it was due to the underdevelopment of the gonads and the anterior pituitary gland and was combined with congenital malformations of internal development.

The first published report of a female with a 45,X karyotype was in 1959 by Dr. Charles Ford and iq option taxas in Harwell near Oxford, and Guy s Hospital in London. 64 It was found in a 14-year-old girl with signs of Turner syndrome. These brokers are recommended to all traders from the UK and have been tried and tested to prove that they can provide an excellent online trading experience. Welcome to the TradersAsset list of UK approved Binary Options brokers.

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Firstlogic Software. Firstlogic data quality software helps marketing departments, data analysts, and fulfillment operations deliver accurate and optimized data, personalized messages and superior customer service. Large, midsize and small companies nationwide rely on Firstlogic s software to increase revenues, cut costs and meet their data quality objectives. On-Premise In-Cloud Software Workflow API Software. On-Premise In-Cloud Software. Firstlogic DQ software is designed for high precision, performance and productivity.

This DQ platform allows your company to run high volumes of data in your secured on-premise data center or an in-cloud data service like Amazon Web Services, Google Cloud or Microsoft Azure. Firstlogic Data Quality DQ. Firstlogic s DQ10 software combines file preparation, address quality, data enhancement, and matching consolidation in a single, comprehensive data quality suite.

Since 1984, data-driven companies have turned to Firstlogic s products to care for some of their most valuable assets the data that fuels their business. Firstlogic data quality software helps marketing departments, data analysts, and fulfillment operations deliver accurate and optimized data, personalized messages and superior customer service for non-SAP applications and data.

Simple, easy-to-use suite of data quality applications for file preparation, address cleansing, geocoding, data cleansing and matching. Ideal for small, mid-size and large data-driven companies and service providers. and Canada address and geocoding data capabilities. Direct access to Microsoft SQL Server, MySQL, Oracle RDBMS, ASCII, delimited, dBase3, or EBCDIC flat files. Simple Job-File development using a text editor or Firstlogic Views User Interface. Batch Integration via Command Line or Real-time Integration via Java, C or.

Process Automation with dynamic Job-File capabilities. Business Benefits. Supported on Windows Linux. Identify moves on your marketing databases and mailing list from those 40 million Americans who move every year and update your list with the new addresses from the USPS LACS Link data directories. Leverage the extensive USPS CASS address directories including ZIP 4eLOTDPVLACS Link ,Suite LinkRDI and Z4Change for more precise addressing cleansing and enhancement.

Increase your postage discounts with USPS DSF 2 processing for high saturation mailings. Target prospects and customers with the precision of latitude and longitude geocoding for pinpoint accuracy at the interpolated rooftop address level or land parcel centroid level. Discover prospect and customer relationships to enable householding techniques to eliminate duplicate mailings and lowering printing and postage costs.

Recognize individual and firm name aliases to assist in consolidating records and creating a single 360-view of individuals and firms for more effective mailing campaigns. Detect individuals and firms to suppress from your mailing list including DMAchoice Do-Not-Mail, deceased, prison, nursing home, bankruptcy and other third party data lists. Create and maintain required USPS Processing Acknowledgement Form PAF information for NCOA Link change of address processing.

Leverage the power of the USPS CASS and LACS Link certified engines built for the ACE platform with over 30 years of proven development. Firstlogic Solutions, LLC is a non-exclusive NCOA Link Interface Distributor Licensee of the USPS. NCOA Link and DSF 2 processing is performed by a non-exclusive licensee of the USPS. The following trademarks are owned by the USPS CASS, CASS Certified, DPV, DSF2, eLOT, LACSLink, NCOALink, Postal Service, RDI, SuiteLink, U.

Postal Service, United States Postal Service, USPS, ZIP 4 and ZIP Code. Data File Preparation. Firstlogic FirstPrep file preparation provides marketers and mailers the ability to define characteristics of their data to be used in processing. Provides a wide variety of customizable features including sort, combine, merge and filter for fast and accurate file preparation.

Provides a critical data review opportunity and allows the prediction of volumes for targeted list segments, versions, or timed distribution. Key Capabilities. Open delimited and fixed-width files of any size or format. Create format and definition files utilized during processing by the Firstlogic DQ 10 suite and link them to the input file. Format Definition allows dynamic format modification of field names, data types, and field lengths, and previews the data with those values.

Definition Field Mapping enables mapping of input file fields to application input fields. View the data with either a Datasheet View showing the field names as column headings, with record data listed below, or with a single-row Record View. Format Editor View allows format modification and shows the data with the defined field names. Count and sort on fields in the data.

Convert file types and merge multiple files into one input file. Utilize Data Selection capabilities to Create reusable data filters and join them together in different combinations based on the business needs. Link filters to specific output files. Count the number of records that will be included in each output file based on data filtering criteria. Finalize your Data Selection and create new output files using the filters and input file selection previously defined.

Firstlogic DQ10 Overview Dirty Data What s It Costing You. Address Correction Encoding. Firstlogic Address Correction Encoding ACE provides USPS CASS address cleansing and geocoding for the United States. Configure the address correction settings for each job using the ACE Views menu-driven interface, create and edit simple job configuration files or integrate into your application. Ensure the accuracy of prospect, customer and vendor location information through USPS CASS Certified address cleansing.

Cleanse your addresses leveraging the USPS ZIP 4carrier routes, eLOTDPVLACS LinkSuite LinkRDI and Z4CHANGE data. Target precise locations of your customers and vendors with address-level and parcel-level latitude and longitude geocoding. US National Directory ZIP 4 Appends data to your addresses such as ZIP 4 codes, carrier routes, and eLOT data. CASS Validates and corrects addresses, ensuring complete, correct, and current data using USPS CASS directories.

DPV Determines if addresses are valid USPS delivery points. LACS Link Converts rural route, highway contract, and rural route box number addresses to street addresses. Suite Link Adds secondary suite information to business addresses. NCOA Link Leverages Firstlogic Mover IQ software to ensure mail delivery to over 40 million Americans who move every year. RDI Determines whether an address is residential or commercial.

Z4CHANGE Provides a cost-effective means of limiting processing to those addresses with ZIP 4 changes in the last 12 months. DSF 2 Ready Generates delivery sequence sorting information, including address information such as seasonal, vacant, residential, and business indicators. Geocoding assign latitude and longitude at the address-level or parcel-level accuracy. CASS Certified Product Firstlogic ACE 08. Parse, standardize and correct your marketing databases and mailing lists using the latest USPS CASS address directories to increase deliverable rates ensuring prospects and customers get your mail piece.

Change of Address. Firstlogic Mover IQ software identifies the millions of consumers and businesses that file USPS NCOA Link change of address notices every year. Proprietary parsing algorithms identify address records for individual family members and businesses. Reduces the billion dollar Undeliverable-as-Addressed UAA problem faced by the USPS every year. Drives higher mail deliverability and greater ROI on mailed communications.

Provides National Change of Address for licensed NCOA Link 18-month End User Mailers EUMLimited Service Providers LSP or 48-month Full Service Providers FSP. NCOA Link Certified Product Firstlogic Mover IQ 6. 5 Firstlogic Solutions, LLC is a non-exclusive NCOA Link Interface Distributor Licensee of the USPS. NCOALink Interface Distribution Required Text Document. Sequence IQ. Delivery Sequence.

Firstlogic Sequence IQ software increases mail deliverability performance leveraging USPS DSF 2 data. Extends the deliverability verification parameters offered by CASS processing alone. Access supplemental information supplied by USPS postal carriers about locations on their routes. Eliminate vacant buildings, empty lots, or seasonally occupied residences and businesses from mailing lists.

Benefit from saturation and high-density postage rate savings. Achieve the highest level of address quality leveraging USPS DSF 2. Companies certify directly with the USPS for DSF 2 certification. USPS DSF 2 Ready Product Firstlogic ACE 08. N Firstlogic Solutions, LLC is a non-exclusive NCOA Link Interface Distributor Licensee of the USPS. DataRight IQ. Data Standardization. Firstlogic DataRight IQ parses, standardizes, and enhances all types of data, including names, firms, email addresses, phone numbers, social security numbers, account numbers, and dates, as well as user-defined patterns and data.

Personalization increases the effectiveness of communications, but your data needs to be in shape to avoid costly mistakes. Ensure your data fields used to control printed content contain legitimate values in every record. DataRight IQ makes the task of standardizing data manageable. Personalize with confidence by using the DataRight IQ tools to manipulate the data. Non-address data parsing, standardization and enhancement.

User-defined pattern matching support. List conversion for up to 255 file and RDBMS table input sources. Intelligent casing. User modifiable dictionaries for parsing and capitalization. Gender determination and pre-name Mr. assignment. Match standards nicknames for individuals i. Margaret and Peg. Search and replace functions. Input and output record filtering. Firstlogic scripting for output field creation or filtering of output data.

Up to 12 lines of floating name and address data within a record. Data Matching Consolidation. Firstlogic Match Consolidate provides powerful data matching, deduplication, householding and consolidation by leveraging sophisticated fuzzy matching algorithms including both deterministic and probabilistic matching techniques to identify unique relationships. Multiple collection sources often cause differences in spelling, data field distribution, formal vs.

informal references and missing elements. Combine data from multiple sources to compile a single view of each customer. Eliminate the expense and embarrassment of producing duplicate mail pieces. Use householding techniques to communicate with customers more effectively. Address and Non-Address data parsing, fuzzy matching and data consolidation. Quickly uncover relationships within one or multiple data sources. Identify duplicates to increase efficiency and reduce costs.

Combine both internal and external data into a single file to create a streamlined view of your customers. Match and consolidate account records to create a single, complete view of customer addresses. Detect and eliminate duplicates so you can delete them from your customer database and mailing lists. Use householding techniques to identify members of the same household or to identify employees of a single company at the corporate level.

Define and implement your own business rules to identify customers within data sets. Process multiple sets of business rules so you can identify hidden relationships in your data. Assign unique identification numbers for records to create relationships between different sets of data. Selectively choose data on a field-by-field basis to build a best consolidated record. Combine records by matching different forms of the same name or firm such as Beth and Elizabeth or AT T and ATT.

Utilize suppression lists to remove records that shouldn t be included in a campaign. Data Enhancement. Firstlogic Enhance IQ provides data quality and enhancement processing for marketing databases and mailing lists. The hybrid software services product includes a single on-premise user interface application where users can build, store and execute jobs that run on a maintenance-free cloud platform with fees charged by the number of records processed.

Address Cleansing Enhancement Canada Address Cleansing Enhancement Data Cleansing Enhancement Data Suppression Data Appending Consumer Demographics Enhancement. Analyze and prepare your marketing databases and direct mailing lists for address cleansing, data cleansing and matching. Simple intuitive UI for creating and managing jobs as well as a repository for storing jobs, job history, and report data.

Create and manage jobs, template jobs and template components. Submit jobs for processing by the cloud service after verifying that the job settings are correct. View recent service history that available from querying the cloud service. Produce PDF reports using stored report data that was returned from the cloud service. View complete history of all jobs submitted to the cloud service for processing including the job settings, who ran it, dates of iq option taxas and completion, reports produced, and all log messages.

Presents data in a format which is easy to view and understand including the ability to filter data based on date range and other criteria as well as the ability to sort the data on screen in ascending or descending order. Utilizes an on-premise repository for management of jobs and templates, storage of report data, logging, and maintaining history of job execution. Enhance IQ allows customers to build, store and run data quality and enhancement jobs to transform their marketing databases and mailing lists using an on-premise application which leverages a maintenance-free data processing backend hosted in the cloud.

No need to update address directories, NCOALink databases, suppression lists or demographic data it s all maintained in the cloud. Address Cleansing Enhancement. CASS address verification NCOA Link change of address DSF 2 walk sequence Geocoding centroid or rooftop level Private change of address PCOA Enhanced change of address ECOA. Canada Address Cleansing Enhancement.

Address standardization Change of address. Data Cleansing Enhancement. Deduplication address, family, or individual level Name parsing Email verification. Deceased default or extended Nursing home Prison Do Not Mail DMA Pander. Reverse phone append Apartment number append Residential phone append Phone disconnected Gender append Cell phone append Name append Do Not Call DMA TPS.

Consumer Demographics Enhancement. Estimated age Age Date of birth Education level Occupation Homeowner Home value Median home value Estimated income Median income Net worth Marital status Children Number of children present Multi-family dwelling unit Dwelling unit size Property type Length of residence Household composition Percent Hispanic Mail order responder general Firstlogic Solutions, LLC is a non-exclusive NCOA Link Interface Distributor Licensee of the USPS.

PAF Manager. Processing Acknowledgement Form Management. The collection of information on the Processing Acknowledgement Form PAF is required by the Privacy Act of 1974 for NCOA Link processing. United States Postal Service USPS requires that each NCOA Link Licensee have a completed PAF for each of their NCOA Link customers prior to providing the services.

Licensee is also required by the USPS to retain a copy of the completed form for each of its customers and to obtain an updated PAF from each of its customers at minimum once per year. Firstlogic PAF Manager is a streamlined Processing Acknowledgement Form PAF information management system for USPS NCOA Link Licensees which allows users to conveniently maintain current PAF data and documentation. Create a new PAF and generate a PDF ready for customer signature. Easily see warnings on PAFs about to expire within a specified timeframe.

Renew and modify an existing PAF. Enter Licensee information once and it will autofill when creating a new PAF. Edit Broker Agent or List Administrator Information. Attach signed forms to a PAF record in the database. Search Display PAF Forms. Comply With USPS PAF Process This tool helps users build their company s PAF procedures and adhere to strict USPS PAF guidelines. Simple User Interface Users can easily search the PAF database to create, renew or modify a PAF, then generate a PAF PDF document ready for signatures.

Simply attach signed PDF s to the PAF database. Easily Manage Required Attachments The application manages attached forms required for the PAF process. Select which forms to copy to renewed or modified PAF s. Save Time Entering Licensee Information Enter licensee information only once. The application auto-populates new PAF s with stored data. Simplify NAICS Data Lookup Import North American Industry Classification System NAICS data and simply lookup the appropriate code without leaving the Firstlogic PAF Manager.

Firstlogic PAF Manager Overview Firstlogic DQ10 Overview Dirty Data What s It Costing You. Workflow API Software. Firstlogic Workflow IQ software is designed for high precision, performance and productivity. This real-time version allows your company to integrate address cleansing, data cleansing and matching capabilities directly into your existing workflows or custom real-time applications via Java. net or C APIs. Workflow IQ.

Net and C API s. Firstlogic Workflow IQ software allows customers to embed address cleansing, data cleansing, matching and enhancement capabilities inside custom workflow applications. Net and C API s ensure the precision, integrity and completeness of data. Maximize developer productivity for operational, analytic, or governance initiatives.

Embed data quality capabilities within your custom workflows and applications using our data quality tools. Simple, light and flexible Java. Net and C APIs for software development ease of use. Integrate U. Address Cleansing options including CASS and NCOA Link 18 48 month. Geocoding to add latitude longitude to addresses. Integrate Data Cleansing for name and firm parsing, standardizing and validating with the pre-built data dictionary. Integrate Matching capability for data de-duplication, relationship identification and householding.

Deploy real-time point of entry validation and matching for potential duplicates. WindowsLinuxAIX Solaris. Contact us to discuss your data quality requirements. Firstlogic Solutions, LLC 3235 Satellite Blvd Ste 300 Duluth, GA 30096-8688. Linkedin Twitter. Firstlogic Solutions Copyrights Trademarks. The following list describes marks that may be used throughout the Firstlogic Solutions web site. These marks are owned by Firstlogic Solutions, LLC or other entities.

This list is not exhaustive and is subject to change. All material, unless otherwise indicated, are copyright Firstlogic Solutions, LLC. Enhance IQ and Precision. are trademarks and Firstlogic, Firstlogic Solutions, FirstPrep, ACE, DataRight IQ, Match Consolidate, PAF Manager, Mover IQ, Sequence IQ, Workflow IQ and Data Quality. SAP and other SAP products and services mentioned herein as well as their respective logos are trademarks or registered trademarks of SAP SE or an SAP affiliate company in Germany and other countries.

are registered trademarks of Firstlogic Solutions, LLC. All other product and service names mentioned are the trademarks of their respective companies. Postal Service, United States Postal Service, USPS, ZIP 4, and ZIP Code. USPS Licensee Notices. SAP America, Inc.

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